Retatrutide Reconstitution & Dosing
Also known as: Triple agonist, LY3437943
Quick answer: mix a 10 mg vial of Retatrutide with 2 ml of bacteriostatic water. That gives 5.00 mg/ml, so a typical 2 mg dose is 40 units on a U-100 insulin syringe — about 5 doses per vial. Reported protocols range 1 mg–12 mg, 1x weekly, titrated up.
Retatrutide is Eli Lilly's investigational triple agonist (GLP-1/GIP/glucagon) that produced ~24% weight loss in phase 2 trials. It is not approved anywhere yet — everything in circulation is research material, making careful reconstitution math even more important. Full overview: what is Retatrutide? →
Calculate your exact dose
Typical range: 1 mg–12 mg, 1x weekly, titrated up
Retatrutide mixing chart — 10 mg vial
Units to draw for a 2 mg dose at different water amounts. More water never changes the dose — only the volume you measure.
| Water added | Concentration | 2 mg dose = | Per unit |
|---|---|---|---|
| 1 ml | 10.00 mg/ml | 20 units | 100.0 mcg |
| 2 ml ← typical | 5.00 mg/ml | 40 units | 50.0 mcg |
| 2.5 ml | 4.00 mg/ml | 50 units | 40.0 mcg |
| 3 ml | 3.33 mg/ml | 60 units | 33.3 mcg |
| 5 ml | 2.00 mg/ml | 100 units | 20.0 mcg |
Protocol reference
FAQ
How much bacteriostatic water do you add to Retatrutide?+
Most protocols mix a 10 mg vial of Retatrutide with 2 ml of bacteriostatic water. This gives 5.00 mg/ml, so a typical 2 mg dose is 40 units on a U-100 insulin syringe. More or less water is fine — it only changes the volume you draw, not the dose.
What is a typical Retatrutide dose?+
Commonly reported Retatrutide protocols use 1 mg to 12 mg, 1x weekly, titrated up, administered via subcutaneous injection. These are reference figures from published protocols, not medical advice — individual use should be guided by a healthcare provider.
How many doses are in a 10 mg vial of Retatrutide?+
At 2 mg per dose, a 10 mg vial contains about 5 doses, regardless of how much water you add.
How should Retatrutide be stored?+
Reconstituted: refrigerate; typically used within 4–8 weeks.
Related peptides
Educational reference only. Values reflect commonly published research protocols and are not medical advice or a recommendation to use any compound. Retatrutide may not be approved for human use in your jurisdiction.