What Is AOD-9604?

AOD-9604 ('Anti-Obesity Drug') is a modified fragment of human growth hormone — the 176-191 tail region responsible for fat metabolism, with a tyrosine added for stability. The design goal: GH's lipolytic effect without its growth, IGF-1 or blood-sugar effects.

It is one of the few peptides here with completed human obesity trials (2000s, Metabolic Pharmaceuticals): safe and modestly effective — statistically significant weight loss that was too small to commercialize. It survives today in body-recomposition protocols, typically dosed fasted.

What is AOD-9604 studied for?

Side effects & safety

Its human trials reported placebo-like tolerability — the cleanest safety showing of the GH-fragment family. Community reports align: occasional injection-site irritation and little else.

Legal & approval status

Not approved as a drug; notably it holds GRAS-adjacent food-ingredient status filings in the US, an oddity among peptides. Sold as a research chemical; WADA-banned in sport.

Typical dosing at a glance

Commonly reported protocols use 250 mcg–500 mcg, daily, often fasted, via subcutaneous injection. For the mixing math — how much bacteriostatic water, exact syringe units, doses per vial — see the AOD-9604 reconstitution calculator →

Related peptides

What is Semaglutide?What is Tirzepatide?What is Retatrutide?What is Cagrilintide?What is HGH Fragment 176-191?

Educational overview based on published research and commonly reported community protocols — not medical advice, and not an endorsement of any compound. Consult a licensed healthcare provider.