What Is Epithalon?

Also known as: Epitalon, AEDG

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a pineal-gland extract studied for decades by the Russian gerontology school of Vladimir Khavinson. It is the flagship molecule of Russian peptide-bioregulator research.

Its headline claim — telomerase activation, potentially slowing the telomere shortening associated with cellular aging — comes from cell studies and small, mostly Russian trials that also reported normalized melatonin rhythms and, in one long-running elderly cohort, reduced mortality. Western replication remains the missing piece.

What is Epithalon studied for?

Side effects & safety

Essentially none reported across its literature — consistent with short cyclic courses of a small endogenous-mimicking molecule. Skeptics note that a compound with dramatic claims and zero side effects deserves proportional skepticism about magnitude.

Legal & approval status

Research chemical in the West; the epithalamin lineage had clinical use in Russia.

Typical dosing at a glance

Commonly reported protocols use 5 mg–10 mg, daily for 10–20 days, cycled 1–2x yearly, via subcutaneous injection. For the mixing math — how much bacteriostatic water, exact syringe units, doses per vial — see the Epithalon reconstitution calculator →

Related peptides

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Educational overview based on published research and commonly reported community protocols — not medical advice, and not an endorsement of any compound. Consult a licensed healthcare provider.