Tesamorelin + Ipamorelin
The premium version of the GHRH + secretagogue play: tesamorelin brings FDA-approval-grade evidence for visceral fat reduction, ipamorelin adds the pulse-trigger synergy with a clean side profile. Longevity clinics adopted this as their flagship body-composition protocol, typically at meaningful monthly cost.
Components & typical mixing
| Peptide | Typical dose | Typical mix | Units/dose |
|---|---|---|---|
| Tesamorelin | 1 mg–2 mg, daily | 5 mg + 2 ml | 80 units = 2 mg |
| Ipamorelin | 200 mcg–300 mcg, 1–3x daily, often before bed | 5 mg + 2 ml | 12 units = 300 mcg |
How the protocol is typically run
- →Tesamorelin: 1–2 mg subcutaneous daily — the trial evidence lives at 2 mg; lower doses are cost-driven extrapolation.
- →Ipamorelin: 200–300 mcg, commonly co-injected in the same pre-bed window.
- →Runs long by peptide standards: visceral-fat trial effects built over 26 weeks, so 3–6 month protocols are the realistic frame, with periodic IGF-1 bloodwork.
Cautions
This is the most expensive stack on this site by monthly cost — decide with a DEXA or waist measurement plan, not hope. GH-axis elevation affects glucose handling; anyone pre-diabetic should be tracking fasting glucose and HbA1c through a long run.
Other stacks
BPC-157 + TB-500 (Wolverine Stack)Ipamorelin + CJC-1295Semaglutide + CagrilintideBPC-157 + KPV (Gut Stack)GHK-Cu + BPC-157 + TB-500 (GLOW)
Educational reference describing commonly published protocols — not medical advice. Most compounds referenced are research chemicals without approval for human use.