What Is KPV?

Also known as: Lysine-Proline-Valine

KPV is a tripeptide (lysine-proline-valine) — the anti-inflammatory tail fragment of alpha-MSH, the melanocortin hormone. By isolating this fragment, researchers kept the inflammation-calming signal while discarding the pigmentation effects of the parent hormone.

Most of its research lives in gut inflammation: rodent colitis models show reduced inflammatory signaling, and its small size lets it enter cells and act on inflammatory pathways directly. It has become the quiet second ingredient in gut-repair protocols alongside BPC-157.

What is KPV studied for?

Side effects & safety

Very little reported — its community profile is one of the mildest, consistent with a small endogenous-fragment molecule. The same caveat applies: minimal human trial data means unknowns rather than proven safety.

Legal & approval status

Research chemical; no approvals. Generally uncontroversial legally as a non-hormonal fragment.

Typical dosing at a glance

Commonly reported protocols use 200 mcg–500 mcg, daily, via subcutaneous injection. For the mixing math — how much bacteriostatic water, exact syringe units, doses per vial — see the KPV reconstitution calculator →

Related peptides

What is BPC-157?What is Pentadeca Arginate (PDA)?What is TB-500?What is GHK-Cu?

Educational overview based on published research and commonly reported community protocols — not medical advice, and not an endorsement of any compound. Consult a licensed healthcare provider.